Genetics of club foot in Maori and Pacific people

Genetics of club foot in Maori and Pacific people.

The role of major gene and multifactorial inheritance in the aetiology of club foot in the New Zealand Polynesian population was studied using 287 New Zealand Maori and Pacific club foot families. The club foot family data were analysed by complex segregation analysis under the mixed model using the computer program POINTER. This analysis shows that the best genetic model for club foot in this ...

Suicide, Mental Illness and Maori People

Globally, authorities and “experts” continually assert that suicide is a major public health concern and it is preventable. However, decades of suicide prevention strategies have seen “more of the same” action plans but no change in the upward suicide trend. Therefore, the current suicide prevention model is less relevant to indigenous and minority populations with a high suicide rate. Current ...

The pulseless club foot.

Previous reports have suggested that the blood supply derived from the anterior tibial artery is absent or markedly diminished in 85% of severe, untreated club feet. To investigate these claims, we used a Doppler technique to study the arterial pulses in 40 children with 63 club feet. In feet with mild or moderate deformities the anterior tibial pulse was always present; in feet with severe def...

Congenital Club-Foot

Sensory hypoinnervation in club foot.

We have compared the density of nerve fibres in the synovium in club foot with that of specimens obtained from the synovium of the hip at operations for developmental dysplasia. The study focused on the sensory neuropeptides substance P; calcitonin gene-related peptide; protein gene product 9.5, a general marker for mature peripheral nerve fibres; and growth associated protein 43, a neuronal ma...